个人简介

博士生导师，课题组组长 ( PI )。主要从事动物生殖发育或动物繁殖比较基因组学、生物信息学和表观遗传学等方面研究。已在Cellular and Molecular Life Science, Journal of Advanced Research, Clinical and translational medicine, Cell Death Differ, Cell Reports等学术期刊发表SCI论文30篇。

获基金资助情况

1. 主持国家自然科学青年科学基金项目（2023.01-2025.12）。
2. 主持中国博士后科学基金面上项目（2021.01-2022.12）。
3. 上海市“超级博士后”激励计划（2020.11.01-2022.10.31）。

近年发表的代表性论文

1. Tian GG#, Hou C#, Li J*, Wu J*. Three‐dimensional genome structure shapes the recombination landscape of chromatin features during female germline stem cell development. Clinical and translational medicine. 2022;  12: e927 (IF: 11.492)
2. Tian GG#, Zhao X#, Hou C#, Xie W, Li X, Wang Y, Wang L, Li H, Zhao X*, Li J*, Wu J*. Integrative analysis of the 3D genome structure reveals that CTCF maintains the properties of mouse female germline stem cells. Cellular and Molecular Life Sciences. 2022; 79: 22 (IF:9.207)
3. Tian GG, Li J*, Wu J*. Alternative splicing signatures in preimplantation embryo development. Cell & Bioscience. 2020; 10: 1-10 (IF: 9.584)
4. Tian GG, Li J*, Wu J*. Comparison analysis of multiple-omics data between femaleline stem cells and spermatogonial stem cells. Genes & Diseases. 2022;  10: 727-730 (IF:7.243)
5. Hou C, Zhao X, Tian GG*, Wu J*. Stella Regulates the Development of   Female Germline Stem Cells by Modulating Chromatin Structure and DNA    Methylation. International journal of biological sciences. 2022; 18:3006   (IF:10.750)
6. Luo H#, Li X#, Tian GG#, Li D, Hou C, Ding X, Hou L, Lyu Q, Yang Y, Cooney AJ, Xie W, Xiong J, Wang H, Zhao X*, Wu J*. Offspring production of ovarian organoids derived from spermatogonial stem cells by defined factors with chromatin reorganization. Journal of Advanced Research. 2021; 33: 81-98 (IF:12.882)
7. Zhao X#, Tian GG#, Fang Q#, Pei X, Wang Z*, Wu J*. Comparison of RNA m(6)A and DNA methylation profiles between mouse female germline stem cells and STO cells. Mol Ther Nucleic Acids. 2021; 23: 431-39 (IF:10.183)
8. Zhang Y#, Tian GG#, Wang X, Hou C, Hu X*, Wu J*. Retinoic acid induced meiosis initiation of female germline stem cells by remodeling       three-dimensional chromatin structure. Cell Proliferation. 2022; 55:      e13242 (8.755)
9. Meng C, Tian G, Xu C, Li X, Zhang Y, Wang Y, Qin J, Fok EKL, Hinton BT, Mak KK, Shum WW, Chan WY, Xia Y*. Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway. Cell Death Differ. 2020; 27: 2797-09 (IF:15.828)
10.  Fang Q, Tian GG, Wang Q, Liu M, He L*, Li S*, Wu J*. YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the lkB-NF-kB-CCND1 axis. Cell Reports. 2023; 42: 112403 (IF 9.995)

（#代表共同第一作者，*代表共同通讯作者）(IF 为近三年最高值)

在投论文

1. Tian GG#, Wu J#, Nie Y#, Cao J, Hou C, Liu W, Cao Y, Wang R, Huang Y, Wu J*,  Qian K*. Single-cell metabolic profiling for remodeling of early embryos. Cell  (under review).

（#代表共同第一作者，*代表共同通讯作者）

人员招聘

欢迎对发育生物学和表观遗传学及生物信息学感兴趣的硕士和博士研究生及博士后加盟。