WANG XU

   Associate Professor

   Department of Plant Science

   Email: xu.wang@sjtu.edu.cn

   Address: Rm513, Bld B, School of Agriculture and Biology

 

 

 

Research Interests

We apply multiple techniques including systems biology, cell biology, genetics to study interplay between mitochondria, nucleus, and other organelles. Following are three main topics:

1. Mitochondrial retrograde signaling in plant development and stress response

2. Mitochondrial stress response and aging

3. Application of systems genetics in mitochondrial research

 

 

Education

Postdoctoral fellow, Oct 2013 to Sep 2018

Swiss Federal Institute of Technology in Lausanne (EPFL)

Supervisor: Prof. Johan Auwerx

Ph.D. in Biology, Jan 2013

Tsinghua University, Beijing, China

Cooperation research at The Chinese University of Hong Kong

Advisor: Prof. Samuel Sun Sai-ming and Dr. Junxian He

M.S. in Biochemistry and Molecular Biology, Jul 2007

Jilin University, Changchun, China

B.S. in Biotechnology, Jul 2004

Jilin University, Changchun, China

 

 

Main achievements

We use QTL mapping, GWAS, and other systems approaches to mechanistically characterize mitochondrial function, aging, and stress response, by measuring mitochondria and stress relevant phenotypes. These studies at the first time revealed mitochondrial unfolded protein response (UPRmt) in plants and its role in regulating plant response to mitochondrial stress.

 

 

Publications:

1. Li H^#, Wang X^#, Rukina D, Huang Q, Lin T, Sorrentino V, Zhang H, Sleiman MB, Arends D, McDaid A, Luan P, Ziari N, Velázquez-Villegas LA, Gariani K, Kutalik Z, Schoonjans K, Radcliffe RA, Prins P, Morgenthaler S, Williams RW, Auwerx J. An integrated systems genetics and omics toolkit to probe gene function. Cell Systems 2018; 6: 90-102. (IF=8.640)

2. Wang X & Auwerx J. Systems phytohormone responses to mitochondrial proteotoxic stress. Molecular Cell 2017; 68: 540-51. (IF=14.548)

3. Stein S^#, Lemos V^#, Xu P, Demagny H, Wang X, Ryu D, Jimenez V, Bosch F, Lüscher TF, Oosterveer MH, Schoonjans K. Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. Journal of Clinical Investigation. 2017; 127(2):583-592. (IF=12.282)

4. Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D'Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ, Auwerx J. NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016; 352(6292):1436-43. (IF=41.037)

5. Moullan N^#, Mouchiroud L^#, Wang X, Ryu D, Williams EG, Mottis A, Jovaisaite V, Frochaux MV, Quiros PM, Deplancke B, Houtkooper RH, Auwerx J. Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research. Cell Reports. 2015; 10(10): 1681–91. (IF=7.815)

6. Jo YS^#, Ryu D^#, Maida A, Wang X, Evans RM, Schoonjans K, Auwerx J. Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. Hepatology. 2015; 62(5):1606-18. (IF=14.971)

7. Wang X^#, Ryu D^#, Houtkooper RH, Auwerx J. Antibiotic use and abuse: a threat to mitochondria and chloroplasts with impact on research, health, and environment. BioEssays 2015; 37(10):1045-53. (IF=4.396)

8. Wang X^#, Bian Y^#, Cheng K, Gu LF, Ye M, Zou H, Sun SSM, He JX. A Large-scale protein phosphorylation analysis reveals novel phosphorylation motifs and phosphoregulatory networks in Arabidopsis. Journal of Proteomics 2013; 78:486-98. (IF=3.537) 

9. Wang YD^#, Wang X^#, Ngai SM, Wong YS. Comparative proteomics analysis of selenium responses in selenium-enriched rice grains. Journal of Proteome Research 2013; 12:808-20. (IF=3.780)

10. Wang YD^#, Wang X^#, Wong YS. Generation of selenium-enriched rice with enhanced grain yield, selenium content and bioavailability through fertilisation with selenite. Food Chemistry 2013; 141:2385-93. (IF=5.399)

11. Wang X, Bian Y, Cheng K, Zou H, Sun SSM, He JX. A comprehensive differential proteomic study of nitrate deprivation in Arabidopsis reveals complex regulatory networks of plant nitrogen responses. Journal of Proteome Research 2012; 11:2301-15. (IF=3.780)

12. Wang YD^#, Wang X^#, Wong YS. Proteomics analysis reveals multiple regulatory mechanisms in response to selenium in rice. Journal of Proteomics 2012; 75:1849-1866. (IF=3.537)

# co-first authors。

Full publication list：

https://www.ncbi.nlm.nih.gov/sites/myncbi/1bszwXerzLSQC/bibliography/41587948/public/?sort=date&direction=descending