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YAN YAXIAN

YAN YAXIAN

 

Professor

Department of Animal Science

Research Interests：Veterinary Molecular Microbiology & Immunology

Phone：+86-21-34206003

Email：yanyaxian@sjtu.edu.cn

Address：Room 207, Zone 3, A Building, School of Agriculture and Biology, 800 Dongchuan Road, Shanghai Jiao Tong University, Shanghai, China, 200240

 

 

>>Current Position

Tenured Professor of Veterinary Molecular Microbiology & Immunology 

Department of Animal Science

School of Agriculture & Biology 

Shanghai Jiao Tong University

 

>>Education

  • B.S., Veterinary Medicine, Nanjing Agricultural University, China
  • M.S., Veterinary Microbiology, Nanjing Agricultural University, China
  • Ph.D., Preventive Veterinary Medicine, Nanjing Agricultural University, China
  • Visiting scholar and joint researcher, Microbiology and Genomics Division, School of Biological Sciences, University of Liverpool, UK

 

 

>>Research Interests

  • Interaction between animal virus and host systems

The research interest is to analyze the molecular mechanism of viral immune escape triggered by virus encoded structural or non-structural proteins, such as porcine delta coronavirus. Most of my work was focusing on the novel innate immune signal molecules and signal transduction pathways in pigs. The results will provide a theoretical basis for analyzing the pathogenic characteristics of the virus, developing new vaccines and drug.

  • The mechanisms employed by bacteria to resist phage infection

It is very important to develop bacteriophage preparations for drug-resistant bacteria. The tolerance of bacteria to bacteriophages is a major problem. We intend to analyze the resist mechanism of host bacteria to bacteriophages and the evolving mechanism of bacteriophages breaking through the tolerance of bacteria, The findings contribute to the application of phages to control antibiotic resistant bacteria infection.

  • Toxicological mechanism and detection technology of mycotoxin

Focus on mycotoxins, we study the molecular signal regulation pathway of mycotoxin induced cytotoxicity. By using quantum dots and group modification, combined with nucleic acid aptamers, we develop a rapid qualitative and quantitative multiple immunoassay method with sensitive and high-throughput. Results provides a theoretical basis for the prevention and control of mycotoxin poisoning, and reserves a detection technology platform for mycotoxins.

 

 

>>Selected Publications

  1. Yuqiang Cheng, Wenxian Zhu, Chan Ding, Qiaona Niu, Hengan Wang, Yaxian Yan, Jianhe Sun. IRF7 Is Involved in Both STING and MAVS Mediating IFN-beta Signaling in IRF3-Lacking Chickens[J]. Journal of Immunology. 2019. 203(7): 1930-1942.
  2. Likai Ji, Shasha Li, Wenxian Zhu, Jingjiao Ma, Jianhe Sun, Hengan Wang, Yaxian Yan. Porcine deltacoronavirus nucleocapsid protein suppressed IFN-beta production by interfering porcine RIG-I dsRNA-binding and K63-linked polyubiquitination [J]. Frontiers in Immunology. 2019, 10(1024).
  3. Likai Ji, Na Wang, Jingjiao Ma, Yuqiang Cheng, Hengan Wang, Jianhe Sun, Yaxian Yan. Porcine deltacoronavirus nucleocapsid protein species-specifically suppressed IRF7-induced type I interferon production via ubiquitin-proteasomal degradation pathway [J]. Veterinary Microbiology. 2020, 250(108853).
  4. Yuqiang Cheng, Yunxia Liu, Shuduan Shi, Qiaona Niu, Wenxian Zhu, Zhaofei Wang, Jingjiao Ma, Hengan Wang, Yaxian Yan, Jianhe Sun. Functional Characterization of Duck STING in IFN-beta Induction and Anti-H9N2 Avian Influenza Viruses Infections[J]. Frontiers in Immunology. 2019. 10: 2224.
  5. Yunxia Liu, Yuqiang Cheng, Wenya Shan, Jingjiao Ma, Hengan Wang, Jianhe Sun, Yaxian Yan. Chicken interferon regulatory factor 1 (IRF1) involved in antiviral innate immunity via regulating IFN-beta production[J]. Developmental and Comparative Immunology. 2018. 88: 77-82.
  6. Denghui Yang, Zhaofei Wang, Jingjiao Ma, Qiang Fu, Lifei Wu, Hengan Wang, Shaohui Wang, Yaxian Yan, Jianhe Sun. Glycine Cleavage System and cAMP Receptor Protein Co-Regulate CRISPR/cas3 Expression to Resist Bacteriophage[J]. Viruses-Basel. 2020, 12, 90.
  7. Zhaofei Wang, Yibing Xue, Ya Gao, Yuanping Liu, Mengting Guo, Xinwei Zou, Yuqiang Cheng, Jingjiao Ma, Hengan Wang, Jianhe Sun and Yaxian Yan. Phage vB_PaeS-PAJD-1 rescues murine mastitis infected with multidrug-resistant Pseudomonas aeruginosa [J]. Frontiers in Cellular and Infection Microbiology. 2021, doi: 10.3389/fcimb.2021.689770.
  8. Zhaofei Wang, Jingjiao Ma, Jian Wang, Denghui Yang, Licheng Kong, Qiang Fu, Yuqiang Cheng, Hengan Wang, Yaxian Yan, Jianhe Sun. Application of the Phage Lysin Ply5218 in the Treatment of Streptococcus suis Infection in Piglets[J]. Viruses-Basel. 2019, 11(8): 0-715.
  9. Qiang Fu ，Shiyu Li ，Zhaofei Wang ，Wenya Shan，Jingjiao Ma，Yuqiang Cheng，Hengan Wang，Yaxian Yan and Jianhe Sun. H-NS Mutation-Mediated CRISPR-Cas Activation Inhibits Phage Release and Toxin Production of Escherichia coli Stx2 Phage Lysogen[J]. Frontiers in Microbiology. 2017, 8：652-663.
  10. Wang Z, Kong L, Liu Y, Fu Q, Cui Z, Wang J, Ma J, Wang H, Yan Y, Sun J. A phage lysin fused to a cell-penetrating peptide kills intracellular methicillin-resistant Staphylococcus aureus in keratinocytes and has potential as a treatment for skin infections in mice. Appl Environ Microbiol, 2018, 84:e00380-18. https://doi.org/10.1128/AEM.00380-18.
  11. Zhaofei Wang, Panpan Zheng,Wenhui Ji, Qiang Fu, HenganWang, Yaxian Yan and Jianhe Sun. SLPW: Avirulent Bacteriophage Targeting Methicillin-Resistant Staphylococcus aureus In vitro and In vivo[J]. Frontiers in Microbiology. 2016, 7:934.
  12. Mengting Guo, Ya Gao, Yibing Xue, Yuanping Liu, Xiaoyan Zeng, Yuqiang Cheng, Jingjiao Ma, Hengan Wang, Jianhe Sun, Zhaofei Wang and Yaxian Yan. Bacteriophage cocktails protect dairy cows against mastitis caused by drug resistant Escherichia coli infection [J]. Frontiers in Cellular and Infection Microbiology. 2021, doi: 10.3389/fcimb.2021.690377.
  13. Silu Hou, Jingjiao Ma, Yuqiang Cheng, Hengan Wang, Jianhe Sun, Yaxian Yan. The toxicity mechanisms of DON to humans and animals and potential biological treatment strategies. Critical reviews in food science and nutrition,2021, DOI: 10.1080/10408398.2021.1954598.
  14. Silu Hou, Jingjiao Ma, Yuqiang Cheng, Hengan Wang, Jianhe Sun, Yaxian Yan. One-step rapid detection of fumonisin B1, dexyonivalenol and zearalenone in grains [J]. Food Control. 2020, 117. https://doi.org/10.1016/j.foodcont.2020.107107.
  15. Silu Hou, Jingjiao Ma, Yuqiang Cheng, Hengan Wang, Jianhe Sun, Yaxian Yan. Quantum dot nanobead-based fluorescent immunochromatographic assay for simultaneous quantitative detection of fumonisin B1, dexyonivalenol, and zearalenone in grains [J]. Food Control. 2020, 117. https://doi.org/10.1016/j. foodcont.2020.107331.
  16. Luming Xia, Quanyun Sun, Jingjing Wang, Qi Chen, Peihong Liu, Chaojian Shen, Jianhe Sun, Yiping Tu, Sufang Shen, Jiuchao Zhu, Hongjin Zhao, Quzhi Wang, Baolong Li, Jun Tao, Ricardo J. Soares Magalhaesf, Yaxian Yan, Chang Cai. Epidemiology of pseudorabies in intensive pig farms in Shanghai, China: Herd-level prevalence and risk factors[J]. Preventive Veterinary Medicine. 2018,159:51-58
  17. Qiang Fu, Zhixin Su, Yuqiang Cheng, Zhaofei Wang, Shiyu Li, Hengan Wang, Jianhe Sun, Yaxian Yan. Clustered, regularly interspaced short palindromic repeat (CRISPR) diversity and virulence factor distribution in avian Escherichia coli [J]. Research in Microbiology. 2016,168:147-156.
  18. YuanKai Wang, Qi Zou, Jianhe Sun, Hengan Wang, Xingmin Sun, ZhiFei Chen, Yaxian Yan. Screening of Single-Stranded DNA (ssDNA) Aptamers against a Zearalenone Monoclonal Antibody and Development of a ssDNABased Enzyme-Linked Oligonucleotide Assay for Determination of Zearalenone in Corn[J]. Journal of agricultural and food chemistry. 2015, 63, 136−141.
  19. Wang Y.K., Shi Y.B., Zou Q., Sun J. H., Chen Z.F., Wang H. a., Li S.Q., Yan Y.X. Development of a rapid and simultaneous immunochromatographic assay for the determination of zearalenone and fumonisin B1 in corn, wheat and feedstuff samples [J]. Food Control. 2013, 31(1): 180-188.
  20. Yuankai Wang, Yaxian Yan, Ziwei Mao, Hengan Wang, Qi Zou, Qianwen Hao, Wenhui Ji, Jianhe Sun. Highly sensitive electrochemical immunoassay for zearalenone in grain and grain-based food [J]. Microchimica Acta. 2013, 180:187–193.
  21. Yuankai Wang, Yaxian Yan, Wenhui Ji, Hengan Wang, Shuqing Li, Qi Zou, Jianhe Sun. Rapid Simultaneous Quantification of Zearalenone and Fumonisin B1 in Corn and Wheat by Lateral Flow Dual Immunoassay[J]. Journal of agricultural and food chemistry. 2013, 61(20): 5031–5036.
  22. Xiangpeng Meng, Yibo Shi, Wenhui Ji, Jianhe Sun, Yaxian Yan. Application of a Bacteriophage lysin to disrupt biofilms formed by the animal pathogen Streptococcus suis[J]. Applied and Environmental Microbiology. 2011,77(23): 8272–8279.

 

 

>>Research Grants

  1. Grantee. The interaction between phages and its host: Development and preclinical evaluation of engineered phages, funded by National Key Research and Development Program of China (NO. 2019YFA0904004), 2020.01-2024.12，¥5,010,000.
  2. Grantee. Molecular mechanism of E.coli thioredoxin DsbA regulating T1-like phage replication, funded by National natural foundation of China (NO. 32072822), 2021.01-2024.12, ¥580,000.
  3. Grantee. The molecular network and regulation on the activation of CRISPR-Cas adaptive immunity mediated by quorum sensing signal molecule AI-2 in Escherichia coli, funded by National natural foundation of China (NO.31772744), 2018.01-2021.12，¥610,000.
  4. Grantee. Hypotoxic and eco-friendly platform for mycotoxins detection based on the chimeric DNA aptamers with mimic toxin epitope, funded by National natural foundation of China (NO. 31571932), 2016.01-2019.12, ¥713,200.
  5. Grantee. Molecular mechanism of interaction between Stx phage superinfection and host CRIPSR immune system，funded by National natural foundation of China (NO. 31272580), 2013.01-2016.12, ¥800,000.
  6. Grantee. Molecular genetic characteristics of bacteriophage VT2 of E.coli O157, such as integration site, vt2 gene and flanking sequence, plaque formation, funded by National natural foundation of China（NO. 30571384）2006-2008, ¥260,000.
  7. Grantee. The rapid, sensitive, and high-throughput detection technology for mycotoxins，funded by National High Technology Research and Development Program of China (NO. 2007AA10Z424), 2007.01-2009.12, ¥670,000.
  8. Grantee. The development of porcine delta coronavirus (PDCoV) inactivated vaccine, funded by Shanghai Municipal Agricultural Commission (NO. 2021-02-08-00-12-F00773), 2021.05-2024.04，¥1,000,000.
  9. Grantee. The development of Virus like particle (VLP) vaccine with chimeric epitopes from porcine delta coronavirus (PDCoV) and porcine epidemic diarrhea virus (PEDV), funded by Shanghai Municipal Agricultural Commission (NO. 2017-1-10), 2017.07-2021.06, ¥1,000,000.
  10. Grantee. The development of detection methods and assay kit for mycotoxins residues in the wheat, funded by Shanghai Science and Technology Foundation (NO.17391901400), 2017.12-2021.12, ¥800,000.
  11. Grantee. Exploration and application demonstration of environmental disinfection mode of microecological agents in intensive dairy farms, funded by Shanghai Science and technology agriculture promotion project: (2019) No. 2-2-19, 2019-2021, ¥200,000.
  12. Grantee. pathogen detection and sensitive drug screening of cow mastitis, funded by Enterprise project:2018-2021, ¥100,000.

 

 

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